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CORONAVIRUS RESEARCH

Experts pour doubt on hydroxychloroquine study that saw WHO ban use for Covid-19


The World Health Organisation has suspended clinical trials with hydroxychloroquine in several countries.
The World Health Organisation has suspended clinical trials with hydroxychloroquine in several countries. AP - John Locher
3 min

More than 100 scientists have raised concerns over a influential study of hydroxychloroquine and chloroquine that led the World Health Organisation to suspend clinical trials to determine if the drugs could be an effective treatment for Covid-19.

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Published last week in The Lancet, the large-scale study suggested the malaria drugs could be dangerous to people with severe cases of Covid-19, increasing the risk of abnormal heart rhythms and even death.

Now, scientists across the world are asking the research team, led by Harvard professor Dr Mandeep Mehra, to release its data for further analysis and independent academic review.

In an open letter, they’ve asked the journal to provide details about the massive hospital database – consisting of 96,000 Covid-19 patients across six continents – which was the basis for the observational study.

So far the authors have declined to release their underlying data, which scientists worry carries several inconsistencies. 

Among them are concerns the average daily doses of hydroxychloroquine, which is cheap and easy to administer, used were higher than the recommended amounts – and that data from Australian patients does not match data from the Australian government. 

Hydroxychloroquine tests around the world were slowed amid concerns over the drug's safety in coronavirus patients.
Hydroxychloroquine tests around the world were slowed amid concerns over the drug's safety in coronavirus patients. John Moore/Getty Images/AFP

The French government last week revoked a decree authorising hospitals to prescribe hydroxychloroquine for Covid-19 patients after France’s public health watchdog warned against its use.

The move came days after the WHO said safety concerns had prompted it to suspend use of the drug in a global trial.

US president Donald Trump has endorsed the use of hydroxychloroquine and says he has been taken the medication prophylactically – despite confusion over whether or not it works against the coronavirus.

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